Institut de Biologie StructuraleGrenoble / France

Master level 2 projects

List of IBS internships available for 2021-2022 in the Chemistry & Biology Department at the UGA

  • Structural investigation of ClpX/ClpP proteolytic machinery in action (details), contact : J. Boisbouvier (IBS/NMR) - Master Biology, Parcours "Structural Biology of Pathogens" - POSITION FILLED
  • Inhibition of the hNTH1-YB1 complex: a new strategy to counter cisplatin
    resistance in solid cancers
    (details), contact : F. Hans (IBS/I2SR) - Master Biology, Parcours "Physiology, Epigenetics, Differentiation, Cancer",
  • Study of cell wall synthesis in a human pathogen using super-resolution fluorescence microscopy (details), contact : C. Morlot (IBS/PG) - Master Biology, Parcours "Structural Biology of Pathogens",
  • Study of the MreD interactome and its role in bacterial fitness and virulence (details), contact : V. Job (IBS/PB&RC) - Master Biology, Parcours "Immunology, Microbiology, Infectious Diseases",
  • Sequencing of proteins using mass spectrometry (details), contact : E. Boeri (IBS/EPIGEN) - Master Biology, Parcours "Structural Biology of Pathogens",
  • Mechanisms of peptidoglycan transpeptidation (details), contact : A. Zapun (IBS/PG) - Master Biology, Parcours "Structural Biology of Pathogens",
  • Protein-induced cross-link of heparan sulfate : structural remodelling of glycocalyx and functional effects (details), contact : R. Sadir (IBS/SAGAG) - Master biologie, Parcours Integrative Structural Biology (ISB)
  • Directed evolution of Influenza virus inhibitors (details), contact : D. Hart (IBS/VRM) - Master biologie, Parcours "Structural Biology of Pathogens" - POSITION FILLED
  • Study and characterization of protein complexes involving HIV-1 Rev and cellular host proteins (details), contact : M. Noirclerc (IBS/EPIGEN) - Master biologie, Parcours "Structural Biology of Pathogens",
  • Study and optimization of the fluorescent protein mScarlet through the analysis of several mutants (details), contact : J. Dupuy (IBS/GSY) - Master biologie, Parcours "Structural Biology of Pathogens",
  • Determination of the structure of bacteriophage T5 Receptor Binding Protein (pb5) by cryo-EM (details), contact : C. Breyton (IBS/M&P) - Master biologie, Parcours "Structural Biology of Pathogens",
  • Study of the kinetics and bacterial cooperation in cell intoxication by Pseudomonas aeruginosa (details), contact : E. Faudry (IBS/PB&RC) - Master biologie, Parcours "Immunology, Microbiology, Infectious Diseases",
  • Study of the MreD interactome and its role in bacterial fitness and virulence (details), contact : V. Job (IBS/PB&RC) - Master biologie, Parcours "Immunology, Microbiology, Infectious Diseases".

List of IBS internships available for 2021-2022 in the Chemistry Department at the UGA

  • Mass spectrometry-based sequencing of soluble and membrane proteins (details), contact : E. Boeri (IBS/EPIGEN) - Master Chimie, Parcours "Chemistry for Life Sciences (CLS)"
  • Study of phototransformable fluorescent proteins photoreactions as a function of the lo-cal physicochemical environment (details), contact : M. Byrdin (IBS/I2SR) - Master Chimie, Parcours "Chemistry for Life Sciences (CLS)"

Scholarships for incoming student

The Chemistry Biology Health Graduate School funds, for students registered at a foreign partner university, scholarships to come to Grenoble for a research internship. Contact (No deadline)

List of IBS internships proposed in 2019-2020 to others UGA Departments:

In the Health Department at the UGA (Master "Ingénierie pour la santé"):

  • Identification & validation of inhibitors of the hNTH1-YB1 interface: a new therapeutic strategy for the treatment of drug-resistant tumours (details), contact : J. Timmins (IBS/VIC)

In the Physics Departments at the UGA (Quantum Matter, Complex Matter Living Matter, Nanochemistry, Nanobiology and Nanophysics):

  • Stress response in bacteria / Electron microscopy (details), contact : I. Gutsche & A. Desfosses (IBS/MICA)
  • Serial protein crystallography: development of a sample delivery system using the Gas Dynamic Virtual Nozzle (GDVN) technology (details), contact : G. Schiro (IBS/DYNAMOP)
  • Can fluorescent proteins be further improved ? (details), contact : M. Byrdin (IBS/DYNAMOP)

Others fundings 2019-2020

  • Master internship (with possibility to pursue in PhD) available to study the contribution of dynamics in the binding of a drug to its biological target using NMR spectroscopy (details), contact: J. Boisbouvier (IBS/NMR)
  • In the framework of the network NeuroCog (IDEX UGA), one internship is funded to study the Functional characterization of a bio-inspired alkaloid for the treatment of Alzheimer’s disease (details); contact : C. Moreau (IBS/MEMBRANE)
  • Master internship available to investigate inorganic nanometric ions capability to solubilize membrane proteins in a functional form (details), contact : C. Ebel (IBS/M&P)
  • Sequencing of proteins using mass spectrometry (details), contact : E. Boeri (IBS/EPIGEN) - Master Biology, Parcours "Structural Biology of Pathogens",
  • Characterization of the megacomplex involved in the biosynthesis of the genotoxin colibactin in E. coli (details), contact : P. Macheboeuf (IBS/PATBAC) - Master Biology, Parcours "Structural Biology of Pathogens",