Master level 2 projects

List of IBS internships available for 2020-2021 in the Chemistry & Biology Department at the UGA

• Exploring the link between the human microbiome and cancer development (details), contact : P. Macheboeuf (IBS/PATBAC) - Master biologie, Parcours Integrative Structural Biology (ISB) - POSITION FILLED

• Structural specificities of HSulf isoforms (details), contact : R. Vivès (IBS/SAGAG) - Master biologie, Parcours Integrative Structural Biology (ISB) - POSITION FILLED

• Molecular insight into heparan sulfate chain elongation (details), contact : R. Wild (IBS/SAGAG) - Master biologie, Parcours Integrative Structural Biology (ISB) - POSITION FILLED

• Structure determination of the DNA polymerase complex of vaccinia virus (details), contact : W. Burmeister (IBS/VRM) - Master biologie, Parcours Integrative Structural Biology (ISB)

• Characterization of the interaction between new recombinant Immunoglobulins M and the complement (details), contact : J.B. Reiser (IBS/IRPAS & Wai Li Ling (IBS/MEM) - Master biologie, Parcours Integrative Structural Biology (ISB) ou Immunology, Microbiology, Infectious Diseases (IMID)

• Cryo-electron microscopy structure of connexin26 (details) ; contact : Wai Li Ling (IBS/MEM) - Master biologie, Parcours Integrative Structural Biology (ISB)

• Structural and dynamical study by NMR of the interactions between bacterial cell-wall components and L.D-transpeptidases in mycobacteria (details), contact : C. Bougault (IBS/NMR) - Master biologie, Parcours Integrative Structural Biology (ISB) - POSITION FILLED

• Structural studies on targeted RNA degradation (details), contact : J. Kadlec (IBS/VIC) - Master biologie, Parcours Integrative Structural Biology (ISB) ou Physiology, Epigenetics, Differentiation, Cancer (PhEDC)

• Characterization of a novel ribosome quality control system in extremophiles (details), contact : B. Franzetti (IBS/ELMA) - Master biologie, Parcours Integrative Structural Biology (ISB)

• Protein-induced clustering of heparan sulfate : structural remodelling of glycocalyx and functional effects (details), R. Sadir (IBS/SAGAG) - Master biologie, Parcours Integrative Structural Biology (ISB)

• Mass spectrometry-based sequencing of soluble and membrane proteins (details), contact : E. Boeri-Erba (IBS/VIC) - Master biologie, Parcours Integrative Structural Biology (ISB)

• Complement C1s in diseases (details), contact : V. Rossi & C. Gaboriaud (IBS/IRPAS) - Master biologie, Parcours Integrative Structural Biology (ISB) ou Immunology, Microbiology, Infectious Diseases (IMID) - POSITION FILLED

• Molecular basis of avian influenza polymerase adaptation to human hosts (details), contact : M. Blackledge (IBS/FDP) - Master biologie, Parcours Integrative Structural Biology (ISB)

• Optimization of the red fluorescent protein mScarlet through mutational and structural analysis (details), contact : J. Dupuy (IBS/GSY) - Master biologie, Parcours Integrative Structural Biology (ISB) ou Immunology, Microbiology, Infectious Diseases (IMID)

• Novel regulation of potassium channels by opioid receptors (details), contact : M. Vivaudou (IBS/CHANNELS) - Master biologie, Parcours Integrative Structural Biology (ISB) ou Neurosciences and Neurobiology

• Design of light-gated potassium channels (details), contact : M. Vivaudou (IBS/CHANNELS) - Master biologie, Parcours Integrative Structural Biology (ISB) ou Neurosciences and Neurobiology

• Revealing the mechanism of action of intrinsically disordered scaffold proteins in MAPK cell signaling by NMR spectroscopy (details), M. Ringkjobing-Jensen (IBS/FDP) - Master biologie, Parcours Integrative Structural Biology (ISB)

List of IBS internships available for 2020-2021 in the Chemistry Department at the UGA

• Structural and dynamical study by NMR of the interactions between bacterial cell-wall components and L,D-transpeptidases in mycobacteria (details), contact : C. Bougault (IBS/NMR) - Master Chemistry, Parcours "Chemistry for Life Sciences (CLS)" - POSITION FILLED

• Structural study of the metal cluster maturation of Nitrogenase (details), contact : M. Cherrier (IBS/METALLO) - Master Chemistry, Parcours "Chemistry for Life Sciences (CLS)"

• Structural characterization of the protein DarE involved in the synthesis of the antibiotic darobactin (details), contact : Y. Nicolet (IBS/METALLO) - Master Chemistry, Parcours "Chemistry for Life Sciences (CLS)"

• Mass spectrometry-based sequencing of soluble and membrane proteins (details), contact : E. Boeri-Erba (IBS/VIC) - Master Chimie, Parcours "Chemistry for Life Sciences (CLS)"

Scholarships for incoming student

The Chemistry Biology Health Graduate School funds, for students registered at a foreign partner university, scholarships to come to Grenoble for a research internship. Contact (No deadline)

List of IBS internships proposed in 2019-2020 to others UGA Departments :

In the Health Department at the UGA (Master "Ingénierie pour la santé") :

• Identification & validation of inhibitors of the hNTH1-YB1 interface : a new therapeutic strategy for the treatment of drug-resistant tumours (details), contact : J. Timmins (IBS/VIC)

In the Physics Departments at the UGA (Quantum Matter, Complex Matter Living Matter, Nanochemistry, Nanobiology and Nanophysics) :

• Stress response in bacteria / Electron microscopy (details), contact : I. Gutsche & A. Desfosses (IBS/MICA)

• Serial protein crystallography : development of a sample delivery system using the Gas Dynamic Virtual Nozzle (GDVN) technology (details), contact : G. Schiro (IBS/DYNAMOP)

• Can fluorescent proteins be further improved ? (details), contact : M. Byrdin (IBS/DYNAMOP)

Others fundings 2019-2020

• Master internship (with possibility to pursue in PhD) available to study the contribution of dynamics in the binding of a drug to its biological target using NMR spectroscopy (details), contact : J. Boisbouvier (IBS/NMR)

• In the framework of the network NeuroCog (IDEX UGA), one internship is funded to study the Functional characterization of a bio-inspired alkaloid for the treatment of Alzheimer’s disease (details) ; contact : C. Moreau (IBS/MEMBRANE)

• Master internship available to investigate inorganic nanometric ions capability to solubilize membrane proteins in a functional form (details), contact : C. Ebel (IBS/M&P)